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A Simple and Effective Skincare Routine for Healthy Skin

woman applying skincare

Maintaining healthy skin requires a consistent skincare routine that supports skin regeneration, hydration, and protection from environmental stressors. A more youthful appearance and healthier skin may be achieved by following a structured morning and evening skincare regimen. 

The Center for Aesthetic Medicine & Surgery at Mayo Clinic

The Center for Aesthetic Medicine & Surgery in Rochester, Minnesota, is a leading multispecialty center dedicated to providing personalized aesthetic care. The expert team collaborates to deliver comprehensive treatments in a state-of-the-art environment tailored to unique needs of patients. 

At the Center for Aesthetic Medicine & Surgery, patients receive exceptional care from world-renowned specialists, including:

  • Dermatologists
  • Facial plastic surgeons
  • Plastic surgeons
  • Oculoplastic surgeons
  • Vascular medicine providers

“At Mayo Clinic’s Center for Aesthetic Medicine and Surgery, we recognize that every individual’s skin is unique. Our approach prioritizes personalized care and science-backed routines that support long-term skin health, regeneration, and protection. By tailoring morning and evening regimens to each patient’s needs, we empower individuals to maintain youthful, resilient skin and optimize their skin longevity.”

Saranya Wyles, MD, PhD, Dermatologist, Mayo Clinic


The following morning and nighttime skincare regimens have been developed in collaboration with the Center for Aesthetic Medicine & Surgery Department at Mayo Clinic in Rochester, Minnesota.

Morning skincare routine

A morning skincare routine should focus on cleansing, hydration, and protection to help prepare skin for the day ahead.

  1. Cleanse: Start the day with a gentle cleanser to remove overnight buildup of oils and impurities without stripping skin’s natural moisture.
  2. Regenerative: Apply a regenerative serum containing peptides or stem cell-derived ingredients to support skin renewal and repair.
  3. Eye Treatment: Use a hydrating and de-puffing eye cream to reduce morning puffiness and fine lines around the delicate eye area.
  4. Antioxidant: Apply an antioxidant serum, such as one containing vitamin C, to help protect the skin from environmental damage caused by free radicals.
  5. Growth Factor: Use a growth factor serum to support collagen production and maintain skin elasticity.
  6. Correct: Target specific skin concerns, such as hyperpigmentation or redness, with a corrective treatment recommended by your dermatologist.
  7. Brighten: Apply a brightening serum or cream to enhance skin radiance and even out the complexion.
  8. Hydrate: Lock in moisture with a lightweight, non-comedogenic moisturizer suitable for the skin type.
  9. Protect: Finish with a broad-spectrum sunscreen (SPF 30 or higher) to shield skin from harmful UV rays and prevent premature aging.

Evening skincare routine

A nighttime routine should focus on cleansing, repair, and deep hydration to support skin recovery while sleeping.

  1. Cleanse: Use a gentle yet effective cleanser to remove makeup, dirt, and excess oil accumulated throughout the day.
  2. Regenerative: Apply a regenerative serum to enhance skin repair and renewal overnight.
  3. Eye Treatment: Use a nourishing eye cream to reduce the appearance of fine lines and improve skin elasticity around the eyes.
  4. Retinol: Incorporate a retinol or retinoid-based product to promote cell turnover, improve texture, and reduce signs of aging.

5. Growth Factor: Apply a growth factor serum to support skin rejuvenation and collagen synthesis.

6. Correct: Use a targeted treatment for concerns such as acne, dark spots, or uneven tone.

7. Hydrate: Seal in moisture with a rich, hydrating night cream or facial oil to maintain skin hydration overnight.

A well-structured skincare routine can significantly enhance skin’s health and appearance. Choose products suited to skin type and concerns and always use sun protection during the day. If there are specific skin conditions or are unsure which products are best, consult a dermatologist for personalized recommendations.

*This article is intended for informational purposes only and should not be substituted for medical advice. For medical questions and advice, it is always best to consult with your trained physician.

Sources:

Addor, F. A. S. (2017). Antioxidants in dermatology. https://pmc.ncbi.nlm.nih.gov/articles/PMC5514576/  

Mayo Clinic. (n.d.). Your Personalized Skin Care Regimen Center for Aesthetic Medicine & Surgery.

Mayo Foundation for Medical Education and Research. (2024, October 15). Center for Aesthetic Medicine & Surgery in Rochester. Mayo Clinic. https://www.mayoclinic.org/departments-centers/rochester-center-aesthetic-medicine-surgery-mayo-clinic/sections/overview/ovc-20519193 

Should I apply my skin care products in a certain order?. American Academy of Dermatology. (n.d.-b). https://www.aad.org/public/everyday-care/skin-care-basics/care/apply-skin-care-certain-order 

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