Phosphatidylserine Explained: What It Is and Why It Matters
- Oct 15, 2025
Phosphatidylserine is a natural fatty substance, known as a phospholipid, that plays an important role in cell function, particularly in the brain. It is found in foods and is also available as a dietary supplement. Research suggests that phosphatidylserine may influence stress response, memory, and other aspects of cognitive health.
What does Phosphatidylserine do to Cortisol?
Cortisol is a hormone released during times of stress. Elevated cortisol levels over time can affect mood, sleep, and overall health. Some studies suggest that phosphatidylserine may help regulate cortisol by lowering its response after exercise or stress. This effect could support resilience to stress and promote a more balanced hormonal response. More research is needed to fully understand how phosphatidylserine affects cortisol in different populations.
What Foods are High in Phosphatidylserine?
Phosphatidylserine is naturally present in certain foods, though typically in small amounts. Dietary sources include:
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Organ meats, such as liver and kidney
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Fatty fish, including mackerel, herring, and tuna
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White beans and soy products
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Egg yolks
Because food sources may not provide high levels, many people who are interested in phosphatidylserine turn to supplements.
Does Phosphatidylserine Help with Brain Fog?
Brain fog describes feelings of mental fatigue, forgetfulness, or lack of clarity. Early research indicates that phosphatidylserine supplements may support memory, attention, and cognitive processing speed, especially in older adults. Some small studies also suggest potential benefits for individuals experiencing stress-related mental fatigue. However, results are mixed, and more large-scale trials are needed before phosphatidylserine can be recommended as a reliable treatment for brain fog.
Is Phosphatidylserine Safe for Children?
Phosphatidylserine supplements have been studied in children, particularly for attention and behavior concerns. Some evidence suggests it may be well tolerated and could offer benefits in specific cases. However, long-term safety data in children are limited. Parents should not start supplements without consulting a pediatrician, who can weigh potential benefits and risks based on a child’s health needs.
Final Thoughts
Phosphatidylserine is a naturally occurring phospholipid that supports brain health and may help regulate cortisol levels. It is found in certain foods and available as a supplement. While research shows promise for stress and cognitive support, evidence remains limited. If you are considering phosphatidylserine, for yourself or your child, speak with a healthcare professional before starting.
*This article is intended for informational purposes only and should not substituted for medical advice. For medical questions and advice, it is always best to consult with your trained physician.
Sources:
Cleveland Clinic. (2025, September 25). Benefits of phosphatidylserine supplements. Cleveland Clinic. https://my.clevelandclinic.org/health/drugs/25129-phosphatidylserine
Duan H;Xu N;Yang T;Wang M;Zhang C;Zhao J;Li Z;Chen Y;Yan J;Zhang M;Li W;Yue Z;Ma F;He R;Huang G; (n.d.). Effects of a food supplement containing phosphatidylserine on cognitive function in Chinese older adults with mild cognitive impairment: A randomized double-blind, placebo-controlled trial. Journal of affective disorders. https://pubmed.ncbi.nlm.nih.gov/39317299/
Ma, X., Li, X., Wang, W., Zhang, M., Yang, B., & Miao, Z. (2022, August 3). Phosphatidylserine, inflammation, and central nervous system diseases. Frontiers in aging neuroscience. https://pmc.ncbi.nlm.nih.gov/articles/PMC9382310/
Starks, M. A., Starks, S. L., Kingsley, M., Purpura, M., & Jäger, R. (2008, July 28). The effects of phosphatidylserine on endocrine response to moderate intensity exercise. Journal of the International Society of Sports Nutrition. https://pmc.ncbi.nlm.nih.gov/articles/PMC2503954/
